Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons.

ABSTRACT:

Background

Hundreds of proteins modulate neurotransmitter release and synaptic plasticity during neuronal development and in response to synaptic activity. The expression of genes in the pre- and post-synaptic neurons is under stringent spatio-temporal control, but the mechanism underlying the neuronal expression of these genes remains largely unknown.

Results

Using unbiased in vivo and in vitro screens, we characterized the cis elements regulating the Rab3A gene, which is expressed abundantly in presynaptic neurons. A set of identified regulatory elements of the Rab3A gene corresponded to the defined Rab3A multi-species conserved elements. In order to identify clusters of enriched transcription factor binding sites, for example, cis-regulatory modules, we analyzed intergeni

SUBMITTER: Liu R 

PROVIDER: S-EPMC2728526 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature