A tool for calculating binding-site residues on proteins from PDB structures.

ABSTRACT:

Background

In the research on protein functional sites, researchers often need to identify binding-site residues on a protein. A commonly used strategy is to find a complex structure from the Protein Data Bank (PDB) that consists of the protein of interest and its interacting partner(s) and calculate binding-site residues based on the complex structure. However, since a protein may participate in multiple interactions, the binding-site residues calculated based on one complex structure usually do not reveal all binding sites on a protein. Thus, this requires researchers to find all PDB complexes that contain the protein of interest and combine the binding-site information gleaned from them. This process is very time-consuming. Especially, combing binding-site information obtained f

SUBMITTER: Hu J 

PROVIDER: S-EPMC2728722 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature