Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches.

ABSTRACT: Of the concepts used to improve the efficiency of organic syntheses, two have been especially effective: atom economy (the use of routes in which most of the atoms present in the reactants also end up in the product) and chemoselectivity (the use of reactions that take place only at desired positions in a molecule). Synthesis of complex natural products is the most demanding arena in which to explore such principles. The bryostatin family of compounds are especially interesting targets, because they combine structural complexity with promising biological activity. Furthermore, synthetic routes to some bryostatins have already been reported, providing a benchmark against which new syntheses can be measured. Here we report a concise total synthesis of bryostatin 16 (1), a parent structure fr

SUBMITTER: Trost BM 

PROVIDER: S-EPMC2728752 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature