A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development.

ABSTRACT: Notch signaling is an evolutionarily conserved pathway essential for many cell fate specification events during metazoan development. We conducted a large-scale transposon-based screen in the developing Drosophila eye to identify genes involved in Notch signaling. We screened 10,447 transposon lines from the Exelixis collection for modifiers of cell fate alterations caused by overexpression of the Notch ligand Delta and identified 170 distinct modifier lines that may affect up to 274 genes. These include genes known to function in Notch signaling, as well as a large group of characterized and uncharacterized genes that have not been implicated in Notch pathway function. We further analyze a gene that we have named Amun and show that it encodes a protein that localizes to the nucleus and co

SUBMITTER: Shalaby NA 

PROVIDER: S-EPMC2728848 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature