Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule.

ABSTRACT: The detailed characterization of synaptic plasticity has led to the replacement of simple Hebbian rules by more complex rules depending on the order of presynaptic and postsynaptic action potentials. Here, we describe a mechanism endowing a plasticity rule with additional computational complexity--a dependence on the pattern of presynaptic action potentials. The classical Hebbian rule is based on detection of conjunctive presynaptic and postsynaptic activity by postsynaptic NMDA receptors, but there is also accumulating evidence for the existence of presynaptic NMDA receptors in several brain structures. Here, we examine the role of presynaptic NMDA receptors in defining the temporal structure of the plasticity rule governing induction of long-term depression (LTD) at the cerebellar parall

SUBMITTER: Bidoret C 

PROVIDER: S-EPMC2729031 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature