Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.

ABSTRACT:

Background

Genome-wide association studies of colorectal cancer (CRC) have identified genetic variants that reproducibly associate with CRC. Associations of 12 single nucleotide polymorphisms at 8q24, 9p24, and 18q21 (SMAD7) and CRC were investigated in a three-center collaborative study including two U.K. case-control cohorts (Sheffield and Leeds) and a U.S. case-control study of CRC cases from high-risk Utah pedigrees.

Methods

Our combined resource included 1,092 CRC case subjects and 1,060 age- and sex-matched controls. Meta statistics and Monte Carlo significance testing using Genie software provided a valid combined analysis of our mixed independent and related case-control resource. We also evaluated whether these associations differed by sex, age at diagnosis, family

SUBMITTER: Curtin K 

PROVIDER: S-EPMC2729170 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature