Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss.

ABSTRACT:

Context

There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children.

Objective

Our objective was to study the longitudinal relationships among RBP4, insulin resistance and weight status in obese children.

Design, setting, and patients

We conducted a 1-yr longitudinal follow-up study in a primary-care setting with 43 obese children (median age 10.8 yr) and 19 lean children of same the age and gender.

Intervention

Our outpatient 1-yr intervention program was based on exercise, behavior, and nutrition therapy.

Main outcomes measures

Changes of weight status (body mass index sd score), RBP4, molar RBP4/serum retinol (SR) ratio,

SUBMITTER: Reinehr T 

PROVIDER: S-EPMC2729181 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature