Association analysis of Kruppel-like factor 11 variants with type 2 diabetes in Pima Indians.

ABSTRACT:

Context

Krüppel-like factor 11 (KLF11) is a transcription factor of the zinc finger domain family that has been shown to regulate expression of the insulin gene. An initial study reported that a KLF11 variant predicting a Q62R was associated with type 2 diabetes (T2D) in French Caucasians; however, subsequent studies have failed to identify an association between this variant and T2D in subjects from a similar Northern-European ancestry.

Objective

We sought to determine whether the Q62R or other variants within KLF11 were associated with T2D in Pima Indians, a population with an extremely high prevalence of this disease.

Design, setting, and subjects

KLF11 was sequenced in 24 Pima Indians to identify potentially novel variants. There were 18 variants genotyped in a fa

SUBMITTER: Ma L 

PROVIDER: S-EPMC2729234 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature