Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.

ABSTRACT:

Background

Gene amplification leading to overexpression is a common event in breast tumors that is linked to tumor development and progression. The 17q23 region is amplified in >40% of breast tumors and contains several candidate oncogenes. Because common genetic variation in several oncogenes has been associated with cancer risk, we assessed the relevance of common variants in the 17q23 candidate oncogenes to breast cancer.

Methods

We investigated 60 polymorphisms in the TUBD1, SEPT4, PRKCA, TBX2, TBX4, TEX14, TLK2, YPEL2, and PPM1E genes from this amplicon for association with breast cancer risk among 798 Caucasian breast cancer cases and 843 unaffected Caucasian controls from the Mayo Clinic.

Results

Eight polymorphisms in PRKCA, TBX4, TLK2, and YPEL2 displayed sig

SUBMITTER: Kelemen LE 

PROVIDER: S-EPMC2729317 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature