Comprehensive mRNA expression profiling distinguishes tauopathies and identifies shared molecular pathways.

ABSTRACT:

Background

Understanding the aetiologies of neurodegenerative diseases such as Alzheimer's disease (AD), Pick's disease (PiD), Progressive Supranuclear Palsy (PSP) and Frontotemporal dementia (FTD) is often hampered by the considerable clinical and molecular overlap between these diseases and normal ageing. The development of high throughput genomic technologies such as microarrays provide a new molecular tool to gain insight in the complexity and relationships between diseases, as they provide data on the simultaneous activity of multiple genes, gene networks and cellular pathways.

Methodology/principal findings

We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with four neurodegenerative disord

SUBMITTER: Bronner IF 

PROVIDER: S-EPMC2729393 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature