Genetic polymorphisms in the Paraoxonase 1 gene and risk of ovarian epithelial carcinoma.

ABSTRACT: Oxidative stress during successive ovulations increases the opportunity for DNA damage to ovarian epithelial cells and the potential for malignant transformation. Paraoxonase 1 (PON1) is an endogenous free radical scavenger that reduces oxidative stress. The association of two common functional single nucleotide polymorphisms (SNP), rs854560 T>A and rs662 A>G, with the risk of epithelial ovarian cancer was examined in a population-based case-control study in Hawaii. A personal interview and blood specimens were collected from 274 women with histologically confirmed, primary ovarian cancer and 452 controls frequency matched on age and ethnicity. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression. Both PON1 SNPs were significantly assoc

SUBMITTER: Lurie G 

PROVIDER: S-EPMC2729507 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature