Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?

ABSTRACT:

Background

: The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate. The human HINT1 gene is located on chromosome 5q31.2, a region implicated in linkage studies of schizophrenia. HINT1 had been shown to have different expression in postmortem brains between schizophrenia patients and unaffected controls. It was also found to be associated with the dysregulation of postsynaptic dopamine transmission, thus suggesting a potential role in several neuropsychiatric diseases.

Methods

: In this work, we studied 8 SNPs around the HINT1 gene region using the Irish study of high density schizophrenia families (ISHDSF, 1350 subjects and 273 pedigrees) and the Irish case control study of schizophrenia (ICC

SUBMITTER: Chen Q 

PROVIDER: S-EPMC2729541 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature