Mathematical modeling supports substantial mouse neural progenitor cell death.

ABSTRACT:

Background

Existing quantitative models of mouse cerebral cortical development are not fully constrained by experimental data.

Results

Here, we use simple difference equations to model neural progenitor cell fate decisions, incorporating intermediate progenitor cells and initially low rates of neural progenitor cell death. Also, we conduct a sensitivity analysis to investigate possible uncertainty in the fraction of cells that divide, differentiate, and die at each cell cycle.

Conclusion

We demonstrate that uniformly low-level neural progenitor cell death, as concluded in previous models, is incompatible with normal mouse cortical development. Levels of neural progenitor cell death up to and exceeding 50% are compatible with normal cortical development and may operate

SUBMITTER: McConnell MJ 

PROVIDER: S-EPMC2729736 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature