Generating rate equations for complex enzyme systems by a computer-assisted systematic method.

ABSTRACT:

Background

While the theory of enzyme kinetics is fundamental to analyzing and simulating biochemical systems, the derivation of rate equations for complex mechanisms for enzyme-catalyzed reactions is cumbersome and error prone. Therefore, a number of algorithms and related computer programs have been developed to assist in such derivations. Yet although a number of algorithms, programs, and software packages are reported in the literature, one or more significant limitation is associated with each of these tools. Furthermore, none is freely available for download and use by the community.

Results

We have implemented an algorithm based on the schematic method of King and Altman (KA) that employs the topological theory of linear graphs for systematic generation of valid react

SUBMITTER: Qi F 

PROVIDER: S-EPMC2729780 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature