LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export.

ABSTRACT:

Background

ATP-binding cassette transporter A1 mediates apolipoprotein AI-dependent efflux of cholesterol and thereby removes cholesterol from peripheral tissues. ABCA1 expression is tightly regulated and deficiency of this cholesterol transporter results in cholesterol accumulation within cells. Low-density lipoprotein receptor-related protein 1 (LRP1) participates in lipid metabolism and energy homeostasis by endocytosis of apolipoprotein E-containing lipoproteins and modulation of cellular proliferation signals.

Methods and principal findings

In the present study, we demonstrate a new role for LRP1 in reverse cholesterol transport. Absence of LRP1 expression results in increased PDGFRbeta signaling and sequential activation of the mitogen-activated protein kinase signalin

SUBMITTER: Zhou L 

PROVIDER: S-EPMC2729921 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature