A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa.

ABSTRACT: Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa. CSS systems sense signals from outside the cell and transmit them into the cytoplasm. They generally consist of a TonB-dependent outer membrane receptor, a sigma factor regulator (or anti-sigma factor) in the cytoplasmic membrane, and an extracytoplasmic function (ECF) sigma factor. Upon perception of the extracellular signal by the receptor the ECF sigma factor is activated and promotes the transcription of a specific set of gene(s). Although most P. aeruginosa CSS systems are involved in the regulation of iron uptake, we have identified a novel system involved in the regulation of virulence. This CSS system, which has

SUBMITTER: Llamas MA 

PROVIDER: S-EPMC2729926 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature