The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae).

ABSTRACT:

Background

Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce an antiviral immune response. Using microarrays, we examined the changes in gene expression in Drosophila that occur in response to infection with the sigma virus, a negative-stranded RNA virus (Rhabdoviridae) that occurs in wild populations of D. melanogaster.

Principal findings

We detected many changes in gene expression in infected flies, but found no evidence for the activation of the Toll, IMD or Jak-STAT pathways, which control immune responses against bacteria and fungi. We identified a number of functional categories of genes, including serine proteases, ribosomal proteins and chorion proteins that were overrepresent

SUBMITTER: Carpenter J 

PROVIDER: S-EPMC2730013 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature