Empirical relationship between intra-purine and intra-pyrimidine differences in conserved gene sequences.

ABSTRACT: DNA sequences seen in the normal character-based representation appear to have a formidable mixing of the four nucleotides without any apparent order. Nucleotide frequencies and distributions in the sequences have been studied extensively, since the simple rule given by Chargaff almost a century ago that equates the total number of purines to the pyrimidines in a duplex DNA sequence. While it is difficult to trace any relationship between the bases from studies in the character representation of a DNA sequence, graphical representations may provide a clue. These novel representations of DNA sequences have been useful in providing an overview of base distribution and composition of the sequences and providing insights into many hidden structures. We report here our observation based on a gr

SUBMITTER: Nandy A 

PROVIDER: S-EPMC2730015 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature