Peptidase substrates via global peptide profiling.

ABSTRACT: Peptide metabolism is a complex process that involves many proteins working in concert. Mass spectrometry-based global peptide profiling of mice lacking dipeptidyl peptidase 4 (DPP4) identified endogenous DPP4 substrates and revealed an unrecognized pathway during proline peptide catabolism that interlinks aminopeptidase and DPP4 activities. Together, these studies elucidate specific aspects of DPP4-regulated metabolism and, more generally, highlight the utility of global peptide profiling for studying peptide metabolism in vivo.

SUBMITTER: Tagore DM 

PROVIDER: S-EPMC2730040 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature