European population genetic substructure: further definition of ancestry informative markers for distinguishing among diverse European ethnic groups.

ABSTRACT: The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4,000 subjects genotyped for 300,000 single-nucleotide polymorphisms (SNPs), we provide further insight into relationships among European population groups and identify sets of SNP ancestry informative markers (AIMs) for application in genetic studies. In general, the graphical description of these principal components analyses (PCA) of diverse European subjects showed a strong correspondence to the geographical relationships of specific countries or regions of origin. Clearer separation of different ethnic and regional populations was observed when northern and southern European groups were considered separat

SUBMITTER: Tian C 

PROVIDER: S-EPMC2730349 | biostudies-literature | 2009 Nov-Dec

REPOSITORIES: biostudies-literature