Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging.

ABSTRACT: Individual differences in the rate of aging are determined by the efficiency with which an organism transforms resources into metabolic energy thus maintaining the homeostatic condition of its cells and tissues. This observation has been integrated with analytical studies of the metabolic process to derive the following principle: The metabolic stability of regulatory networks, that is the ability of cells to maintain stable concentrations of reactive oxygen species (ROS) and other critical metabolites is the prime determinant of life span. The metabolic stability of a regulatory network is determined by the diversity of the metabolic pathways or the degree of connectivity of genes in the network. These properties can be empirically evaluated in terms of transcriptional changes in gene exp

SUBMITTER: Brink TC 

PROVIDER: S-EPMC2730443 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature