The functional neuroanatomy of geriatric depression.

ABSTRACT:

Objective

Positron Emission Tomography (PET) studies of cerebral glucose metabolism have demonstrated sensitivity in evaluating the functional neuroanatomy of treatment response variability in depression, as well as in the early detection of functional changes associated with incipient cognitive decline. The evaluation of cerebral glucose metabolism in late life depression may have implications for understanding treatment response variability, as well as evaluating the neurobiological basis of depression in late life as a risk factor for dementia.

Methods

Sixteen patients with geriatric depression and 13 comparison subjects underwent resting PET studies of cerebral glucose metabolism, as well as magnetic resonance (MR) imaging scans to evaluate brain structure.

Results

SUBMITTER: Smith GS 

PROVIDER: S-EPMC2730507 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature