Using biological performance similarity to inform disaccharide library design.

ABSTRACT: Designing better small-molecule discovery libraries requires having methods to assess the consequences of different synthesis decisions on the biological performance of resulting library members. Since we are particularly interested in how stereochemistry affects performance in biological assays, we prepared a disaccharide library containing systematic stereochemical variations, assayed the library for different biological effects, and developed methods to assess the similarity of performance between members across multiple assays. These methods allow us to ask which subsets of stereochemical features best predict similarity in patterns of biological performance between individual members and which features produce the greatest variation of outcomes. We anticipate that the data-analysis ap

SUBMITTER: Tanikawa T 

PROVIDER: S-EPMC2730776 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature