Cortical reorganization following anterior temporal lobectomy in patients with temporal lobe epilepsy.

ABSTRACT:

Background

Functional MRI was used to study the impact of temporal lobe epilepsy (TLE) and anterior temporal lobectomy (ATL) on the cortical language network in patients with medically refractory TLE.

Methods

Nineteen patients with medically refractory TLE and 11 healthy control subjects were enrolled in this study. Ten patients underwent left ATL (mean age 35.2 +/- 3.8 years), and 9 underwent right ATL (mean age 35.9 +/- 2.6 years). The subjects silently generated verbs in response to a series of visually presented nouns inside the scanner. Correlation analysis was performed between the subjects' performance on the clinical language tests and their neural response in the a priori cortical regions.

Results

Preoperative data revealed that the patients with TLE showed i

SUBMITTER: Wong SW 

PROVIDER: S-EPMC2730795 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature