Transcriptome analysis of Taenia solium cysticerci using Open Reading Frame ESTs (ORESTES).

ABSTRACT:

Background

Human infection by the pork tapeworm Taenia solium affects more than 50 million people worldwide, particularly in underdeveloped and developing countries. Cysticercosis which arises from larval encystation can be life threatening and difficult to treat. Here, we investigate for the first time the transcriptome of the clinically relevant cysticerci larval form.

Results

Using Expressed Sequence Tags (ESTs) produced by the ORESTES method, a total of 1,520 high quality ESTs were generated from 20 ORESTES cDNA mini-libraries and its analysis revealed fragments of genes with promising applications including 51 ESTs matching antigens previously described in other species, as well as 113 sequences representing proteins with potential extracellular localization, with obvio

SUBMITTER: Almeida CR 

PROVIDER: S-EPMC2731055 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature