Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection.

ABSTRACT:

Aim

To analyze the correlation between CD14 rs2569190/C-159T single nucleotide polymorphism (SNP) and disease progression in chronic hepatitis C.

Methods

Liver biopsy specimens from a total of 137 and 349 patients with chronic hepatitis C were separately evaluated with respect to necroinflammatory activity (grading) and architectural changes (staging). In one group, further histological lesions characteristic for hepatitis C, hepatitis C virus subtypes, and biochemical parameters of liver disease were also investigated. Samples of genomic DNA were genotyped for the respective SNP by 5'-nuclease assays using fluorescent dye-labeled allele-specific probes.

Results

Genotype distribution did not deviate from the Hardy-Weinberg equilibrium. In the first group, patients hom

SUBMITTER: Askar E 

PROVIDER: S-EPMC2731250 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature