Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy.

ABSTRACT:

Background

Cardiac hypertrophy is classically regarded as a compensatory response, yet the active tissue remodeling processes triggered by various types of mechanical stress can enhance or diminish the function of the heart. Despite the disparity in outcomes, there are similarities in the hypertrophic responses. We hypothesized that a generic genetic response that is not dependent on the particular nature of the hypertrophic stimulus exists. To test our hypothesis, we compared the temporal evolution of transcriptomes measured in hearts subjected to either adaptive (exercise-induced) or maladaptive (aortic banding-induced) hypertrophy.

Methods and results

Generic hypertrophy-associated genes were identified and distinguished from stimulus-dependent transcripts by coupling a m

SUBMITTER: Sheehy SP 

PROVIDER: S-EPMC2731432 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature