A systematic meta-analysis of genetic association studies for diabetic retinopathy.

ABSTRACT:

Objective

Diabetic retinopathy is a sight-threatening microvascular complication of diabetes with a complex multifactorial pathogenesis. A systematic meta-analysis was undertaken to collectively assess genetic studies and determine which previously investigated polymorphisms are associated with diabetic retinopathy.

Research design and methods

All studies investigating the association of genetic variants with the development of diabetic retinopathy were identified in PubMed and ISI Web of Knowledge. Crude odds ratios (ORs) and 95% CIs were calculated for single nucleotide polymorphisms and microsatellite markers previously investigated in at least two published studies.

Results

Twenty genes and 34 variants have previously been studied in multiple cohorts. The aldose r

SUBMITTER: Abhary S 

PROVIDER: S-EPMC2731535 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature