EvoRSR: an integrated system for exploring evolution of RNA structural robustness.

ABSTRACT:

Background

Robustness, maintaining a constant phenotype despite perturbations, is a fundamental property of biological systems that is incorporated at various levels of biological complexity. Although robustness has been frequently observed in nature, its evolutionary origin remains unknown. Current hypotheses suggest that robustness originated as a direct consequence of natural selection, as an intrinsic property of adaptations, or as a congruent correlate of environment robustness. To elucidate the evolutionary origins of robustness, a convenient computational package is strongly needed.

Results

In this study, we developed the open-source integrated system EvoRSR (Evolution of RNA Structural Robustness) to explore the evolution of robustness based on biologically important

SUBMITTER: Shu W 

PROVIDER: S-EPMC2731758 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature