Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure.

ABSTRACT:

Rationale

Fluoroquinolones are the most commonly prescribed antibiotic class in the United States. They have the potential to become first-line antituberculosis therapy, but the effect of fluoroquinolone use on fluoroquinolone resistance in Mycobacterium tuberculosis is not well characterized.

Objectives

To determine the prevalence of and risk factors for fluoroquinolone-resistant tuberculosis in a large United States population.

Methods

We identified all people with culture-confirmed tuberculosis enrolled in TennCare (Medicaid) and reported to the Tennessee Department of Health from January 2002 to December 2006. People with fluoroquinolone-resistant M. tuberculosis isolates (cases) were compared with those with susceptible isolates (control subjects). Fluoroquinolon

SUBMITTER: Devasia RA 

PROVIDER: S-EPMC2731810 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature