Serum lipopolysaccharide activity is associated with the progression of kidney disease in finnish patients with type 1 diabetes.

ABSTRACT:

Objective

The aim of the study was to investigate whether serum lipopolysaccharide (LPS) activities are associated with the progression of kidney disease in patients with type 1 diabetes.

Research design and methods

For this prospective study, we chose 477 Finnish patients with type 1 diabetes, who were followed for 6 years. At the baseline visit, 239 patients had a normal albumin excretion rate (normoalbuminuria) and 238 patients had macroalbuminuria. Patients were further divided into nonprogressors and progressors based on their albumin excretion rate at follow-up. Eighty normoalbuminuric patients had developed microalbuminuria, and 79 macroalbuminuric patients had progressed to end-stage renal disease. Serum LPS activity was determined with the Limulus amoebocyte lysate

SUBMITTER: Nymark M 

PROVIDER: S-EPMC2732155 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature