Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells.

ABSTRACT:

Motivation

In the human genome, 'CpG islands', CG-rich regions located in or near gene promoters, are normally unmethylated. However, in cancer cells, CpG islands frequently gain methylation, resulting in silencing of growth-limiting tumor suppressor genes. To our knowledge, the potential relationship between CpG island hypermethylation, transcription factor (TF) binding in local promoter regions and transcriptional control has not been previously explored in a genome-wide context.

Results

In this study, we utilized bioinformatics tools and TF binding site(TFBs) databases to globally analyze sequences methylated in a laboratory model for the development of drug-resistant cancer. Our results demonstrated that four TFBS were enriched in hypermethylated sequences. More interest

SUBMITTER: Li M 

PROVIDER: S-EPMC2732208 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature