ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth.
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ABSTRACT: Unlabelled
Many important problems in biology involve complex traits affected by multiple coding or regulatory parts of the genome. How well the underlying genetic architecture can be inferred by statistical methods such as mapping and association studies are active research areas. ForSim is a flexible forward evolutionary simulation tool for exploring the consequences of evolution by phenotype, whereby demographic, chance, behavioral and selective effects mold genetic architecture. Simulation is useful for exploring these issues as well as the choice of study design inferential methods.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Lambert BW
PROVIDER: S-EPMC2732213 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth.
Lambert Brian W BW Terwilliger Joseph D JD Weiss Kenneth M KM
Bioinformatics (Oxford, England) 20080619 16
<h4>Unlabelled</h4>Many important problems in biology involve complex traits affected by multiple coding or regulatory parts of the genome. How well the underlying genetic architecture can be inferred by statistical methods such as mapping and association studies are active research areas. ForSim is a flexible forward evolutionary simulation tool for exploring the consequences of evolution by phenotype, whereby demographic, chance, behavioral and selective effects mold genetic architecture. Simu ...[more]
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