MotifMap: a human genome-wide map of candidate regulatory motif sites.

ABSTRACT:

Motivation

Achieving a comprehensive map of all the regulatory elements encoded in the human genome is a fundamental challenge of biomedical research. So far, only a small fraction of the regulatory elements have been characterized, and there is great interest in applying computational techniques to systematically discover these elements. Such efforts, however, have been significantly hindered by the overwhelming size of non-coding DNA regions and the statistical variability and complex spatial organizations of mammalian regulatory elements.

Results

Here we combine information from multiple mammalian genomes to derive the first fairly comprehensive map of regulatory elements in the human genome. We develop a procedure for identifying regulatory sites, with high levels of con

SUBMITTER: Xie X 

PROVIDER: S-EPMC2732295 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature