A novel comprehensive wave-form MS data processing method.

ABSTRACT:

Motivation

Mass spectrometry (MS) can generate high-throughput protein profiles for biomedical research to discover biologically related protein patterns/biomarkers. The noisy functional MS data collected by current technologies, however, require consistent, sensitive and robust data-processing techniques for successful biomedical application. Therefore, it is important to detect features precisely for each spectrum, quantify them well and assign a unique label to features from the same protein/peptide across spectra.

Results

In this article, we propose a new comprehensive MS data preprocessing package, Wave-spec, which includes several novel algorithms. It can overcome several conventional difficulties. Wave-spec can be applied to multiple types of MS data generated with di

SUBMITTER: Chen S 

PROVIDER: S-EPMC2732299 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature