Ontology highlight
ABSTRACT:
SUBMITTER: Basma H
PROVIDER: S-EPMC2732349 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Basma Hesham H Soto-Gutiérrez Alejandro A Yannam Govardhana Rao GR Liu Liping L Ito Ryotaro R Yamamoto Toshiyuki T Ellis Ewa E Carson Steven D SD Sato Shintaro S Chen Yong Y Muirhead David D Navarro-Alvarez Nalu N Wong Ronald J RJ Roy-Chowdhury Jayanta J Platt Jeffrey L JL Mercer David F DF Miller John D JD Strom Stephen C SC Kobayashi Naoya N Fox Ira J IJ
Gastroenterology 20081029 3
<h4>Background & aims</h4>The ability to obtain unlimited numbers of human hepatocytes would improve the development of cell-based therapies for liver diseases, facilitate the study of liver biology, and improve the early stages of drug discovery. Embryonic stem cells are pluripotent, potentially can differentiate into any cell type, and therefore could be developed as a source of human hepatocytes.<h4>Methods</h4>To generate human hepatocytes, human embryonic stem cells were differentiated by s ...[more]