SscMap: an extensible Java application for connecting small-molecule drugs using gene-expression signatures.

ABSTRACT:

Background

Connectivity mapping is a process to recognize novel pharmacological and toxicological properties in small molecules by comparing their gene expression signatures with others in a database. A simple and robust method for connectivity mapping with increased specificity and sensitivity was recently developed, and its utility demonstrated using experimentally derived gene signatures.

Results

This paper introduces sscMap (statistically significant connections' map), a Java application designed to undertake connectivity mapping tasks using the recently published method. The software is bundled with a default collection of reference gene-expression profiles based on the publicly available dataset from the Broad Institute Connectivity Map 02, which includes data from ove

SUBMITTER: Zhang SD 

PROVIDER: S-EPMC2732627 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature