Accelerating epistasis analysis in human genetics with consumer graphics hardware.

ABSTRACT:

Background

Human geneticists are now capable of measuring more than one million DNA sequence variations from across the human genome. The new challenge is to develop computationally feasible methods capable of analyzing these data for associations with common human disease, particularly in the context of epistasis. Epistasis describes the situation where multiple genes interact in a complex non-linear manner to determine an individual's disease risk and is thought to be ubiquitous for common diseases. Multifactor Dimensionality Reduction (MDR) is an algorithm capable of detecting epistasis. An exhaustive analysis with MDR is often computationally expensive, particularly for high order interactions. This challenge has previously been met with parallel computation and expensive hardw

SUBMITTER: Sinnott-Armstrong NA 

PROVIDER: S-EPMC2732631 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature