Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants.

ABSTRACT:

Background

Attention-deficit hyperactivity disorder (ADHD) is an important psychiatric condition in terms of its prevalence and impact on quality of life. It has one of the highest heritabilities found in psychiatric disorders. A number of association studies exploring several candidate genes in different populations around the world have been carried out. The objective of the present study was to carry out a meta-analysis for 8 common variants located in 5 top candidate genes for ADHD (BDNF, HTR1B, SLC6A2, SLC6A4 and SNAP25); these genes are known to be involved in synaptic transmission and plasticity.

Methods

We performed a search for published genetic association studies that analyzed the candidate polymorphisms in different populations, and we applied state-of-the-art me

SUBMITTER: Forero DA 

PROVIDER: S-EPMC2732742 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature