Asymptotic tests of association with multiple SNPs in linkage disequilibrium.

ABSTRACT: We consider detecting associations between a trait and multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD). To maximize the use of information contained in multiple SNPs while minimizing the cost of large degrees of freedom (DF) in testing multiple parameters, we first theoretically explore the sum test derived under a working assumption of a common association strength between the trait and each SNP, testing on the corresponding parameter with only one DF. Under the scenarios that the association strengths between the trait and the SNPs are close to each other (and in the same direction), as considered by Wang and Elston [Am. J. Hum. Genet. [2007] 80:353-360], we show with simulated data that the sum test was powerful as compared to several existing tests; other

SUBMITTER: Pan W 

PROVIDER: S-EPMC2732754 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature