Promoter activity 5' of Dbeta2 is coordinated by E47, Runx1, and GATA-3.

ABSTRACT: V(D)J recombination involves the stepwise assembly of B and T cell receptor genes as lymphocytes progress through the early stages of development. While the mechanisms that restrict each step in recombination to its appropriate developmental stage are largely unknown, they share many of the components that regulate transcription. For example, enhancer-dependent modifications in histone acetylation and methylation are essential for both germline transcription and rearrangement of antigen receptor genes. Promoters positioned proximal to individual D and J gene segments in Tcra, Tcrb, Tcrd, IgH, and Igk also contribute to antigen receptor gene assembly, though their effects appear more localized than those of enhancers. Tcrb assembly initiates with D-to-J joining at each of the two D-J-C gene

SUBMITTER: McMillan RE 

PROVIDER: S-EPMC2732994 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature