Gene expression changes following extinction testing in a heroin behavioral incubation model.

ABSTRACT:

Background

A number of gene expression studies have investigated changes induced by drug exposure, but few reports describe changes that persist following relapse. In this study, genome-wide analysis of gene expression was conducted following an extinction session (90 min) in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. As an important modulator of goal-directed behavior, the medial prefrontal cortex (mPFC) was the target of genomic analysis. Rats were trained to self-administer heroin during 3 h daily sessions for 14 d. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session in which they could seek heroin, but received none. Extinction sessions were conducted

SUBMITTER: Kuntz-Melcavage KL 

PROVIDER: S-EPMC2733140 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature