Using cases and parents to study multiplicative gene-by-environment interaction.

ABSTRACT: With case-parent triads, one can estimate genotype relative risks by measuring the apparent overtransmission of susceptibility genotypes from parents to affected offspring. Results obtained using such designs, properly analyzed, resist both bias due to population structure and bias due to self-selection. Most diseases are not purely genetic, and environmental cofactors can also be important. In this paper, the authors describe how a polytomous logistic regression method previously developed for studying genetic effects on a quantitative trait can be used with case-parent data to study multiplicative gene-by-environment interaction. The idea is that if the joint effect of exposure and genotype on risk is submultiplicative or supermultiplicative, then, conditional on the parental genotypes,

SUBMITTER: Kistner EO 

PROVIDER: S-EPMC2733309 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature