Revealing modular architecture of human brain structural networks by using cortical thickness from MRI.

ABSTRACT: Modularity, presumably shaped by evolutionary constraints, underlies the functionality of most complex networks ranged from social to biological networks. However, it remains largely unknown in human cortical networks. In a previous study, we demonstrated a network of correlations of cortical thickness among specific cortical areas and speculated that these correlations reflected an underlying structural connectivity among those brain regions. Here, we further investigated the intrinsic modular architecture of the human brain network derived from cortical thickness measurement. Modules were defined as groups of cortical regions that are connected morphologically to achieve the maximum network modularity. We show that the human cortical network is organized into 6 topological modules that c

SUBMITTER: Chen ZJ 

PROVIDER: S-EPMC2733312 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature