Cannabinoid receptor 1 gene association with nicotine dependence.

ABSTRACT:

Context

The endogenous cannabinoid system has been implicated in drug addiction in animal models. The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain. It has been reported to be associated with alcoholism and multiple drug abuse and dependence.

Objective

To test the hypothesis that the CNR1 gene is associated with nicotine dependence.

Design

Genotype-phenotype association study. Ten single-nucleotide polymorphisms were genotyped in the CNR1 gene in 2 independent samples. For the first sample (n = 688), a 3-group case-control design was used to test allele association with smoking initiation and nicotine dependence. For the second sample (n = 961), association was assessed with scores from the Fagerström Test for Nicotine Dependence (F

SUBMITTER: Chen X 

PROVIDER: S-EPMC2733353 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature