Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis.

ABSTRACT:

Objectives

To evaluate the comparative efficacy and tolerability of topical calcipotriol in the treatment of mild to moderate chronic plaque psoriasis.

Design

Quantitative systematic review of randomised controlled trials.

Subjects

6038 patients with plaque psoriasis reported in 37 trials.

Main outcome measures

Mean difference in percentage change in scores on psoriasis area and severity index, and response rate ratios for both patients' and investigators' overall assessments of marked improvement or better. Adverse effects were estimated with the rate ratio, rate difference, and number needed to treat.

Results

Calcipotriol was at least as effective as potent topical corticosteroids, calcitriol, short contact dithranol, tacalcitol, coal tar, and combined

SUBMITTER: Ashcroft DM 

PROVIDER: S-EPMC27334 | biostudies-literature | 2000 Apr

REPOSITORIES: biostudies-literature