Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer.

ABSTRACT:

Background

Secondary analyses of two randomized, controlled phase III trials demonstrated that selenium and vitamin E could reduce prostate cancer incidence. To characterize pharmacodynamic and gene expression effects associated with use of selenium and vitamin E, we undertook a randomized, placebo-controlled phase IIA study of prostate cancer patients before prostatectomy and created a preoperative model for prostatectomy tissue interrogation.

Methods

Thirty-nine men with prostate cancer were randomly assigned to treatment with 200 microg of selenium, 400 IU of vitamin E, both, or placebo. Laser capture microdissection of prostatectomy biopsy specimens was used to isolate normal, stromal, and tumor cells. Gene expression in each cell type was studied with microarray analysi

SUBMITTER: Tsavachidou D 

PROVIDER: S-EPMC2734116 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature