Positive and negative selection on noncoding DNA in Drosophila simulans.

ABSTRACT: There is now a wealth of evidence that some of the most important regions of the genome are found outside those that encode proteins, and noncoding regions of the genome have been shown to be subject to substantial levels of selective constraint, particularly in Drosophila. Recent work has suggested that these regions may also have been subject to the action of positive selection, with large fractions of noncoding divergence having been driven to fixation by adaptive evolution. However, this work has focused on Drosophila melanogaster, which is thought to have experienced a reduction in effective population size (N(e)), and thus a reduction in the efficacy of selection, compared with its closest relative Drosophila simulans. Here, we examine patterns of evolution at several classes of nonc

SUBMITTER: Haddrill PR 

PROVIDER: S-EPMC2734132 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature