Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study.

ABSTRACT:

Background

Digital pulse amplitude augmentation in response to hyperemia is a novel measure of peripheral vasodilator function that depends partially on endothelium-derived nitric oxide. Baseline digital pulse amplitude reflects local peripheral arterial tone. The relation of digital pulse amplitude and digital hyperemic response to cardiovascular risk factors in the community is unknown.

Methods and results

Using a fingertip peripheral arterial tonometry (PAT) device, we measured digital pulse amplitude in Framingham Third Generation Cohort participants (n=1957; mean age, 40+/-9 years; 49% women) at baseline and in 30-second intervals for 4 minutes during reactive hyperemia induced by 5-minute forearm cuff occlusion. To evaluate the vascular response in relation to baseline

SUBMITTER: Hamburg NM 

PROVIDER: S-EPMC2734141 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature