A balanced diet is necessary for proper entrainment signals of the mouse liver clock.

ABSTRACT:

Background

The peripheral circadian clock in mice is entrained not only by light-dark cycles but also by daily restricted feeding schedules. Behavioral and cell culture experiments suggest an increase in glucose level as a factor in such feeding-induced entrainment. For application of feeding-induced entrainment in humans, nutrient content and dietary variations should be considered.

Principal finding

To elucidate the food composition necessary for dietary entrainment, we examined whether complete or partial substitution of dietary nutrients affected phase shifts in liver clocks of mice. Compared with fasting mice or ad libitum fed mice, the liver bioluminescence rhythm advanced by 3-4 h on the middle day in Per2::luciferase knock-in mice that were administered a standard mo

SUBMITTER: Hirao A 

PROVIDER: S-EPMC2734168 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature